Nano/microsystem creation based on nano-bio-cell fusion and its application

Project Gist

Establishment of new academic field by Nanotechnology, Biology and Cell Engineering fusion

Keywords

nanotechnology, biology, body, cell, membrane

Background, Purpose, and Project Achievements

This project aims to establish a new academic field and its application to life-innovation based on nano/micro-system realized by nano-bio-cell fusion technology through the collaboration with Swiss Federal Institute of Technology, Zurich. Significant achievements have been obtained in the area of; SWCNT-DNA fusion technology for the ultrasensitive sensors, Body on a Chip technology to realize a microfluidic system consists of cultivated 3D cells as a small organs integrate into a closed-loop medium circulation system for rapid drug screening and safety testing, an ultrafast method for observing single-molecule movement in the plasma membrane.

Future Prospects

A nano/micro-system realized by nano-bio-cell fusion technology has great potential. We will continue our effort toward the establishment of this field by strengthening the collaboration in both research and education with ETHZ.

Figures

Schematic design of the body-on-a-chip fabricated by soft lithography using PDMS-bilayer structure. It consists of two cell culture chambers (220 µm in height), microchannels (45 µm in height) for linking two organs　(Liver and Heart), an on-chip hydraulic-driven micro valves, and a peristaltic micro pump for closed-loop circulation.

Principal Investigator

・TABATA Osamu
・Graduate School of Engineering
・The aim of my research is the establishment of “Synthetic Engineering of Nanoscale Systems (SENS)” to realize micro/nanosystems with novel and unique functions by integrating functional elements in different domains such as mechanics, electronics, chemistry, optics and biotechnology.
・http://www.nms.me.kyoto-u.ac.jp/

FY2013: Project Achievements and Future Prospects Listへ戻る