Research Support

An Exploration of Novel Biomarkers for Cognitive Function Using Gaze Analyzer

Project Gist

Establish an objective evaluation of cognitive function


mild cognitive impairment, MCI, eye tracking gaze analysis

Background and Purpose

Dementia has become a major social issue in developed countries with aging populations. Early detection of mild cognitive impairment (MCI), which is a preliminary stage of dementia, is important because it has been shown that appropriate treatment may prevent progression to dementia. In this study, we aim to detect dementia at an early stage by using gaze latency and gaze transition obtained from a gaze analyzing perimetry (GAP) developed by Kyoto University and FINDEX Inc.

Project Achievements

Our project was applied for and adopted by the Japan Agency for Medical Research and Development (AMED), the Medical Engineering Collaboration and Artificial Intelligence Implementation Research Project. Principal Investigator of the SPIRITS project, Masahiro Miyake, also served as Principal Investigator on the AMED project. I closely collaborate with the Department of Neurology and the Department of Psychiatry Neurology at Kyoto University Hospital, the Nagahama Study conducted in collaboration with the Center for Genomic Medicine and Nagahama City, Shiga Prefecture, the Shizuoka Cohort conducted in cooperation with Shizuoka Prefecture and the Shizuoka University of Social and Health Medicine, and the Japan Ocular Imaging Registry, a national database established by the Japanese Ophthalmological Society. This AMED project is totally managed by MIYAKE Masahiro.

Future Prospects

We will continue to collect data in community-based cohort studies and in actual dementia patients to explore eye movements closely related to cognitive dysfunction. We will consult with the regulatory authorities in order to obtain regulatory approval.


Gaze analyzing perimetry
Measurement using gaze analyzing perimetry

Principal Investigator

MIYAKE Masahiro

MIYAKE Masahiro
Department of Ophthalmology, Kyoto University Hospital
He is an Ophthalmologist at Kyoto University Hospital. He got his Ph.D. degree at Kyoto University Graduate School of medicine, and M.P.H. at Harvard School of Public Health. His expertise in clinical practice is macular disorders, vitreoretinal diseases, an myopiaa. His research expertise includes clinical research, genetic studies, epidemiology, and artificial intelligence.
Twitter: @eyemiyake