Elucidate spatio-temporal landscape of blood cells
Project Gist
To clarify the spatiotemporal dynamics of hematopoietic stem cells.
Keywords
Hematopoietic stem cells, single cell analysis, peripheral organs, repair, mathematical modeling
Background and Purpose
Blood cells produced from HSCs circulate throughout the body and are considered to be closely related to peripheral organs. In order to elucidate the relationship between HSCs and other organs, we aim to analyze how all blood cells are produced from HSCs and how they change over time by collecting spatio-temporal data and using both mathematical modeling and data-driven approaches.
Project Achievements
A new and extensive research network was formed, allowing for new collaborations and team building. In addition, the team was able to prepare an application for a large competitive external fund.
Future Prospects
We would like to apply for and obtain large competitive funds based on the research results and networks obtained through the support of SPIRITS, and to elucidate the relationship between hematopoietic stem cells and all organs and tissues.
Figure
Databanking of spatio-temporal dynamics of hematopoietic differentiation lineages
derived from single hematopoietic stem cells
Principal Investigator
YAMAMOTO Ryo
Institute for the Advanced Study, Institute for the Advanced Study of Human Biology
The hematopoietic system is maintained by hematopoietic stem cells, but the essential nature of this system has not yet been elucidated. Their goal is to understand the essence of the hematopoietic system through interdisciplinary research using mouse, monkey, and human models, and integrating the latest measurement techniques and computational science.
Related URL: https://ashbi.kyoto-u.ac.jp/lab-sites/ryo-yamamoto/
