Medical Device Development in Cardiac Disease

Project Gist

Establishment of the Center for the Development of Medical Devices for iPS Cell in Cardiovascular Diseases

Keywords

Cardiovascular Diseases、Medical Device Development、iPS cell

Background and Purpose

　Regenerative medicine such as iPS cell therapy has achieved remarkable results in recent years, but only a few of them have been applied clinically. This situation is due to the fact that it is seed-driven development. This may be partly due to the fact that no strategy has been developed for the process of clinical trials and manufacturing and marketing, starting with preclinical studies.
　This project aims to create a ecosystem that enables the development of medical devices using iPS cells unique to Kyoto University by using the biodesign method, a needs-driven medical device development method, in the field of cardiovascular diseases.

Project Achievements

　A hands-on workshops on the 3D intracardiac potential mapping system (CARTO ®) was held. Although communication between companies usually does not deepen in a short period of time, a shared sense of purpose led to a meaningful exchange of opinions. These led to a leap forward in the development of catheters to inject iPS cells into the heart, and the final concept device was decided upon.
　By participating in several domestic academic conferences, it was possible to conduct educational activities for companies and other academia.
　Through these activities, we have also received offers for joint research from companies, and various projects have been launched.

Future Prospects

　The final concept for the catheter has been determined and is being prepared for clinical trials. The Cardiovascular Medicine Bridging Research Group was established in recognition of the industry-academia collaboration in this project. I would like to focus on encouraging and training young researchers as well as developing the group.

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Principal Investigator